Heterogeneity of Ex Vivo and In Vivo Properties along the Length of the Abdominal Aortic Aneurysm

The current clinical guidelines for the management of aortic abdominal aneurysms (AAAs) overlook structural and mechanical heterogeneity tissue its role in regional weakening that drives disease progression. This study is a comprehensive investigation biomechanical AAA along length circumference aorta, by means ex vivo properties. Biaxial testing histological analysis were performed on human specimens systematically collected during open repair surgery. Wall-shear stress three-dimensional principal strain to allow characterization individual aortas. A marked effect position was observed both properties, with central regions corresponding aneurysmal sac being significantly different from adjacent regions. aorta reflected biaxial response at low strains Present findings uniquely show importance assessment need correlate level non-invasive measurements aimed improving outcomes.